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MRCPUK SEND Exam Syllabus Topics:

SectionObjectives
Topic 1: General Endocrinology- Integrated Clinical Practice
  • 1. Endocrine hypertension
  • 2. Investigation, imaging and interpretation of endocrine tests
  • 3. Genetic endocrine syndromes
  • 4. Neuroendocrine disorders
Topic 2: Diabetes Mellitus- Management
  • 1. Technology and glucose monitoring
  • 2. Oral and injectable therapies
  • 3. Insulin therapy
  • 4. Lifestyle interventions
- Diagnosis and Classification
  • 1. Gestational diabetes
  • 2. Type 1 diabetes
  • 3. Other specific types of diabetes
  • 4. Type 2 diabetes
- Complications
  • 1. Perioperative and inpatient diabetes management
  • 2. Microvascular complications
  • 3. Acute metabolic emergencies
  • 4. Macrovascular complications
Topic 3: Calcium and Bone Metabolism- Parathyroid and Metabolic Bone Disease
  • 1. Disorders of calcium, phosphate and vitamin D metabolism
  • 2. Hypoparathyroidism
  • 3. Osteoporosis
  • 4. Hyperparathyroidism
Topic 4: Adrenal Disorders- Adrenal Disease
  • 1. Cushing syndrome
  • 2. Primary aldosteronism
  • 3. Adrenal insufficiency
  • 4. Pheochromocytoma and adrenal incidentaloma
Topic 5: Thyroid Disorders- Thyroid Disease
  • 1. Thyroid nodules and cancer
  • 2. Thyroiditis and special clinical situations
  • 3. Hypothyroidism
  • 4. Hyperthyroidism
Topic 6: Reproductive Endocrinology- Gonadal Disorders
  • 1. Female reproductive endocrinology
  • 2. Male hypogonadism
  • 3. Disorders of puberty and fertility
  • 4. Polycystic ovary syndrome
Topic 7: Pituitary and Hypothalamic Disorders- Pituitary Disease
  • 1. Pituitary tumors
  • 2. Hypothalamic disorders
  • 3. Pituitary hormone deficiency
  • 4. Pituitary hormone excess

MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

1. A 44-year-old man was referred for investigation of cortisol excess. He had poorly controlled hypertension, and a long history of type 2 diabetes mellitus with retinopathy and peripheral neuropathy. His medication comprised aspirin, ramipril, atenolol, carbamazepine, metformin and simvastatin.
Initial investigations:
serum cortisol (09.00 h)350 nmol/L (200-700)
serum cortisol (22.00 h)48 nmol/L (50-250)
overnight dexamethasone suppression test (after 1 mg dexamethasone):
serum cortisol93 nmol/L (<50)
24-h urinary free cortisol (day 1)225 nmol (55-250)
24-h urinary free cortisol (day 2)200 nmol (55-250)
24-h urinary free cortisol (day 3)185 nmol (55-250)
What is the most appropriate next step in management?

A) high-dose 48-h dexamethasone suppression test
B) MR scan of pituitary
C) CT scan of adrenal glands
D) reassure and discharge
E) dexamethasone-suppressed corticotrophin-releasing hormone test


2. A 67-year-old woman with type 2 diabetes mellitus presented to the foot clinic with an ulcer at the plantar aspect of her fifth left toe. The ulcer probed to bone but there were no signs of inflammation. There had been a little improvement during 6 weeks of podiatric treatment, but there was some concern about possible osteomyelitis. An X-ray of toe 4 weeks previously had been normal.
What is the most appropriate next investigation?

A) triple phase isotope bone scan
B) CT scan of foot
C) white cell labelled scan
D) MR scan of foot
E) plain X-ray of foot


3. A 72-year-old woman was referred for bone density assessment after sustaining a fracture of her right ankle after a minor fall. She had previously fractured her right wrist after tripping in the street. Her past medical history included occasional angina relieved by glyceryl trinitrate spray and a previous deep venous thrombosis. Her medication comprised aspirin, simvastatin, alendronic acid, and calcium and vitamin D, which she had been taking regularly for 2 years.
Investigations:
DXA scan of spine (L2-L4)T score -2.4
DXA scan of total hipT score -2.8
What is the most appropriate treatment?

A) switch alendronic acid to pamidronate
B) switch alendronic acid to strontium ranelate
C) switch alendronic acid to raloxifene
D) continue alendronic acid
E) switch alendronic acid to teriparatide


4. A 46-year-old South Asian man presented with a 2-month history of dry mouth and polyuria. He had hypertension treated with bendroflumethiazide. There was no family history of diabetes mellitus, but his father had died suddenly during lower limb angioplasty at the age of 51.
On examination, the patient's pulse was 76 beats per minute and regular, and his blood pressure was 164/86 mmHg. The rest of the physical examination was normal. Urinalysis was normal.
Investigations:
serum sodium143 mmol/L (137-144)
serum potassium3.0 mmol/L (3.5-4.9)
serum creatinine123 umol/L (60-110)
fasting plasma glucose6.9 mmol/L (3.0-6.0)
What is the most appropriate next step in management?

A) start oral hypoglycaemic treatment
B) haemoglobin A1c measurement
C) repeat fasting plasma glucose
D) change bendroflumethiazide to ramipril
E) oral glucose tolerance test


5. A 50-year-old woman with acromegaly presented with persistent sweating and headaches
despite having undergone trans-sphenoidal surgery and pituitary radiotherapy 2 years
previously. She had been intolerant of treatment with octreotide.
Investigations:
serum growth hormone11.1 ?g/L (<0.4)
serum insulin-like growth factor 186.2 nmol/L (5.6-23.3)
Following imaging, it was judged that there was no role for repeat surgery. She was treated
with pegvisomant 10 mg. Six months into treatment, her symptoms had improved.
Investigations (6 months later):
serum growth hormone20.3 ?g/L (<0.4)
serum insulin-like growth factor 115.2 nmol/L (5.6-23.3)
What is the most appropriate next step in management?

A) stop pegvisomant
B) add cabergoline
C) arrange another full course of pituitary radiotherapy
D) increase dosage of pegvisomant
E) continue present dosage of pegvisomant


Solutions:

Question # 1
Answer: D
Question # 2
Answer: E
Question # 3
Answer: D
Question # 4
Answer: D
Question # 5
Answer: E

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